Tagged: clinical trial

October 2018 Newsletter

Posted on October 16, 2018

October 2018 Newsletter

ClinSearch would like to keep you up to date.

Our monthly newsletter details new studies and events happening at our site. Our website has several resources to learn more about the clinical trials process. We encourage you to read and share these links with friends and family who may be interested.

Volunteer Referral Program

Suggest a friend and receive a $50 referral bonus.
Learn more here

 Featured Studies

Rosacea clinical trial
Uterine Fibroids

Planning your life around heavy periods shouldn’t be the norm. Consider a research study for uterine fibroids.

Learn more here:
Uterine Fibroids Study

Overactive Bladder clinical trial
Overactive Bladder (OAB)

If you are a women who experiences the symptoms of OAB, consider joining our clinical research study.

Learn more here:
OAB Study

Crohn’s Disease

If you have moderate to severely active Crohn’s Disease and are between 18 to 75 years of age, you may qualify for our current study.

Learn more here:
Crohn’s Disease Study

Other Studies

Check out our complete list of enrolling volunteer studies here…

Active clinical trial studies

Want to be notified whenever a new volunteer study matches your interests?

Complete a volunteer sign-up form

July 2018 Newsletter

Posted on July 15, 2018

July 2018 Newsletter

ClinSearch would like to keep you up to date.

Our monthly newsletter details new studies and events happening at our site. Our website has several resources to learn more about the clinical trials process. We encourage you to read and share these links with friends and family who may be interested.

Volunteer Referral Program

Suggest a friend and receive a $50 referral bonus.
Learn more here

 Featured Studies

NASH Clinical Trial
Nonalcoholic Steatohepatitis (NASH)

We are currently enrolling for a clinical research study for the treatment of cirrhosis from NASH. Learn more about participating in this study:
NASH Study

Gastroparesis Clinical Trial
Gastroparesis

Gastroparesis is a condition in which your stomach cannot empty itself of food in a normal fashion. Learn more about participating in a clinical study for this condition here:
Gastroparesis Study

Sjogren’s Syndrome

Dry mouth and eyes from Sjogren’s syndrome? If so, you may qualify for a clinical research study at ClinSearch examining an investigational medication for individuals with Sjogren’s syndrome. Learn about the study here:
Sjogren’s syndrome study

Other Studies

Check out our complete list of enrolling volunteer studies here…

Active clinical trial studies

Want to be notified whenever a new volunteer study matches your interests?

Complete a volunteer sign-up form

November Newsletter 2017

Posted on November 3, 2017

Featured Studies

Nonalcoholic Fatty Liver Disease (NAFLD) NAFLD is liver inflammation caused by a buildup of fat in the liver. We are enrolling volunteers with NAFLD in a placebo-controlled study testing an investigational medication.

Learn about the study here.

 

Ulcerative Colitis

Do you experience the discomfort of ulcerative colitis? If so, you may qualify for a clinical research study that we are enrolling.

Visit our website to learn more about this study.

 


Fibromyalgia
We are studying a new treatment for Fibromyalgia. Patients must be 18-79 with a confirmed diagnosis of fibromyalgia. Other qualifications may apply.

There is no cost for this study, and you may be compensated for your time and travel. Visit our website to learn more and to see if you qualify.

 

Other Studies

Eczema (Atopic Dermatitis)

Do you or a loved one suffer from eczema, also known at atopic dermatitis? We are enrolling volunteers in a clinical research study for individuals with eczema.

Learn more here.

 

Acne

We are enrolling volunteers who experience acne. If you are at least 9 years old, you may qualify for a clinical research trail.

Visit us here to learn more.

 

Gastroparesis

Gastroparesis is a condition in which your stomach cannot empty itself of food in a normal fashion. If you are interested in participating in one of our Gastroparesis studies, visit us here.

 

Crohn’s Disease

There are 1.4 million Americans with Crohn’s disease. ClinSearch is conducting new research on the treatment of this disease.

Check out Dr. Krause’s recent blog post to learn more about this condition and the studies we are doing here at ClinSearch.

 


Sjorgren’s Syndrome

Dry mouth and eyes from Sjogren’s syndrome? If so, you may qualify for a clinical research study at ClinSearch examining an investigational medication for individuals with Sjogren’s syndrome. Learn about the study here.

 

Nonalcoholic Steatohepatitis or Fatty Liver?

We are currently enrolling for a clinical research study for the treatment of cirrhosis from NASH. Visit our website to find out more about this study.

October Newsletter 2017

Posted on October 16, 2017

Read our latest blog post to learn about
Crohn’s Disease, Ulcerative Colitis and You.

Featured Studies

Nonalcoholic Steatohepatitis or Fatty Liver?
ClinSearch is currently enrolling for a clinical research study for the treatment of cirrhosis from NASH. Visit our website to find out more about this study.

 

 

 

Acne
ClinSearch is enrolling volunteers who experience acne. If you are at least 9 years old, you may qualify for a clinical research trail. Visit us here to learn more.

 

 

 

Eczema (Atopic Dermatitis)
Do you or a loved one suffer from eczema, also known at atopic dermatitis? ClinSearch is enrolling volunteers in a clinical research study for individuals with eczema. Learn more here.

 

 

 

Other Studies

 

Fibromyalgia
We are studying a new treatment for Fibromyalgia. Patients must be 18-79 with a confirmed diagnosis of fibromyalgia. Other qualifications may apply.
There is no cost for this study and you may be compensated for your time and travel. Visit our website to learn more and to see if you qualify.

 

 

 

Ulcerative Colitis
Do you experience the discomfort of ulcerative colitis? If so, you may qualify for a clinical research study at ClinSearch. Visit our website to learn more about this enrolling study.

 

 

 

Gastroparesis
Gastroparesis is a condition in which your stomach cannot empty itself of food in a normal fashion. If you are interested in participating in one of our Gastroparesis studies, visit us here.

 

 

 

Crohn’s Disease
There are 1.4 million Americans with Crohn’s disease. ClinSearch is conducting new research on the treatment of this disease.
Check out Dr. Krause’s recent blog post to learn more about this condition and the studies we are doing here at ClinSearch.

 

 

Sjorgren’s Syndrome
Dry mouth and eyes from Sjogren’s syndrome? If so, you may qualify for a clinical research study at ClinSearch examining an investigational medication for individuals with Sjogren’s syndrome. Learn about the study here.

 

September Newsletter 2017

Posted on September 5, 2017

Featured Studies

Ulcerative Colitis

Do you experience the discomfort of ulcerative colitis? If so, you may qualify for a clinical research study at ClinSearch.

Visit our website to learn more about this enrolling study.

 

IBS-C or IBS-D

Do you suffer with the symptoms of irritable bowel syndrome? Volunteers with either IBS-C or IBS-D are needed for current studies at our site.

Visit us for more information about IBS-C and IBS-D.

 
 

Gastroparesis

Gastroparesis is a condition in which your stomach cannot empty itself of food in a normal fashion.

If you are interested in participating in one of our Gastroparesis studies, visit us here.

 
 

Other Studies

Fibromyalgia
We are studying a new treatment for Fibromyalgia. Patients must be 18-79 with a confirmed diagnosis of fibromyalgia. Other qualifications may apply.

There is no cost for this study and you may be compensated for your time and travel.

Visit our website to learn more and to see if you qualify.

 
 

Crohn’s Disease
There are 1.4 million Americans with Crohn’s disease. ClinSearch is conducting new research on the treatment of this disease.
Check out Dr. Krause’s recent blog post to learn more about this condition and the studies we are doing here at ClinSearch.

 
 
 

Nonalcoholic Steatohepatitis or Fatty Liver?

ClinSearch is currently enrolling for a clinical research study for the treatment of cirrhosis from NASH.

Visit our website to find out more about this study.

 
 
 

Type 2 Diabetes and High Triglycerides

If you have type 2 diabetes and high triglycerides you may qualify for a study at ClinSearch.

Find out more here.

 
 

Type 1 and Type 2 Diabetes

ClinSearch will be enrolling studies for individuals with either Type 1 or Type 2 diabetes. If you experience either of these conditions you may qualify for our clinical research studies.

To learn more visit our website here.

 
 

Sjorgren’s Syndrome

Dry mouth and eyes from Sjogren’s syndrome? If so, you may qualify for a clinical research study at ClinSearch examining an investigational medication for individuals with Sjogren’s syndrome.

Learn about the study here.

August Newsletter 2017

Posted on August 1, 2017

Acne Study

Is your acne getting in your way? ClinSearch is enrolling a study for individuals suffering from acne. Visit our website to learn more about this study: Link

 
 
 

Crohn’s Disease

There are 1.4 million Americans with Crohn’s disease. ClinSearch is conducting new research on the treatment of this disease.
Check out Dr. Krause’s latest blog post to learn more about this condition and the studies we are doing here at ClinSearch.

 
 
 

Type 2 Diabetes and High Triglycerides

If you have type 2 diabetes and high triglycerides you may qualify for a study at ClinSearch.
Find out more here.

 
 
 

Fibromyalgia

We are studying a new treatment for Fibromyalgia. Patients must be 18-79 with a confirmed diagnosis of fibromyalgia. Other qualifications may apply.
There is no cost for this study and you may be compensated for your time and travel. Visit our website to learn more and to see if you qualify.

 
 
 

Human LiverNonalcoholic Steatohepatitis or Fatty Liver?

Nonalcoholic steatohepatitis or NASH is liver inflammation caused by a buildup of fat in the liver. Dr. Krause has written about this topic to help individuals better understand this condition on his blog.
ClinSearch is currently enrolling for a clinical research study for the treatment of cirrhosis from NASH. Visit our website to find out more about this study.

 
 
 

Atopic Dermatitis (Eczema)

Eczema is a condition that affects 2-10% of adults in the United States. ClinSearch is enrolling individuals who have eczema in a clinical research study. If you suffer from this condition and would like to participate, visit our website here to learn more about getting involved.  Additionally, if you are interested in learning about this condition you can read what Dr. Krause has to say here.

 
 
 

Migraines

Do you suffer from migraines? If the pain of migraine headaches is getting in your way, you may qualify for a clinical research study at ClinSearch.
Visit us online to learn more: link

 
 
 

Want to know more about participating in clinical research? Read more on our website.

Clinical Trials Lead to Better Care

Posted on May 27, 2015

Clinical Trails are Critical in Bringing New Drugs to Market

Written by Mike Haskew Updates by Melissa Watson

Research and development are critical components of progress in any field, and in medicine the introduction of new drugs is heavily dependent on the clinical trial.

Pharmaceutical companies are continually producing new medications, but the effectiveness of any one of them cannot be measured with any degree of accuracy until a group of actual patients gives it a try. Across the country, clinical research facilities solicit patients to participate in studies which take place prior to or soon after the approval of a new medication by the Food and Drug Administration. One of these facilities, ClinSearch, has been operating here in Chattanooga for nearly 2 decades.

Founded in 1990 by Dr. Richard Krause, a local gastroenterologist, ClinSearch has enrolled over 11,440 patients in more than 290 studies and developed relationships with almost 100 different pharmaceutical companies. ClinSearch has become such a major player in the clinical research field that it is a fixture in the top 10 percent in numbers of study participants.

Dr. Krause became involved with clinical research in 1992 for a couple of reasons. “I could see the writing on the wall,” he remembered. “Insurance companies were manipulating patients to go to particular doctors whether they wanted to go to them or not, and being involved with clinical trials gave me the opportunity to see patients that I would otherwise never see.”

Basically, a clinical trial is a research study initiated and funded by a pharmaceutical company and conducted by medical professionals who evaluate treatments or procedures. Quite simply, today’s clinical trials lead to tomorrow’s standard care.

Clnical research is conducted on four different levels at Clinsearch. A phase 1 study involves monitoring the progress of relatively healthy patients to make sure that a certain drug is safe. In Phase 2, a drug has been determined to be safe on a relatively small number of people, and the drug is administered to a larger number. Phase 3 includes the fine tuning of dosages and other criteria specific to the drug. Occasionally, a pharmaceutical company will commission a Phase 4 study, which may also be known as a post-marketing study, to compare its drug’s performance to that of a competitor after FDA approval.

“At the end of Phase 3, the data and results from clinical studies are presented to the FDA,” explained Dr. Krause, “and the FDA may take months or even years to give its approval. They do have a fast track they can put a drug on for approval if it is brand new or if there is a disease that no other drug can combat. Prilosec, one of the first proton pump inhibitors to be used for heartburn, was put on the fast track, for example.”

Clinsearch was involved in the study for Prilosec, and the process was typical. “We advertised for volunteers,” said Dr. Krause, “telling them that they would be trying a new drug and that they might get a sugar pill (placebo), or the real drug. We were looking for people over 18 who were experiencing heartburn on a regular basis. In the beginning, because we don’t know the proper dosage, there will usually be four arms in a study. These arms receive the low, middle, and high doses, and one of them gets the placebo. Because we are fine tuning in Phase 3, this type of study may only have two arms.”

Dr. Krause is selective with the studies in Phase 2 & 3. “I pick and choose the ones we get involved with,” he said, “based on whether or not I think the drug is safe or the study is important. Before we do a Phase 3, we get the chance to review the results of Phase 2, but Phase 2 is the most fun because it is on the cutting edge.”

To date, ClinSearch has conducted clinical trials on such ailments as Celiac Disease, Chronic Constipation, Migraines, Acne, IBS, and more.

According to Dr. Krause, recruiting patients is not a difficult thing to do. “I would bet that half our patients come by word of mouth from friends or relatives who have heard of us or participated in previous studies. The people of Chattanooga have been very willing to participate. Some of them may come through my office after talking to me or seeing us advertise,” said the native of Philadelphia who came to Chattanooga in 1997.

“I may suggest a study to the patient if they aren’t responding to current therapy, and we don’t take a patient off current medication if they are responding,” the doctor continued. “We don’t try to convince people to go into a study. We just expose them to the information. If someone has heartburn and they aren’t responding to treatment, they might be interested in a study. We give a lengthy explanation of the pros and cons to the patients and discuss the risks, which are the unknown and the potential side effects.”

Throughout the course of a clinical trial, it is clear that the health and welfare of the patient are the primary concerns. While it might appear to the layman that talking a drug is safest after FDA approval, it is actually safer during the trial. Each study participant is provided with a document called an informed consent form, which describes the risks, benefits and expectations of the study in detail. Because the patients are monitored closely, any adverse effects or developments are discovered early.

“I explain to patients that our research studies are really safer than taking a brand new drug which just came on the market,” commented Dr. Krause, who completed his internship and residency at Grady Hospital in Atlanta through Emory University, and his GI fellowship at Yale University. “We monitor patients much more closely than a private physician could. We don’t have to get approval from an insurance company to run an EKG or a blood test because the drug company is paying for it. The drug companies usually require monthly blood tests while the patient is in the study, and the reason for this is that most drug side effects occur in the liver or the kidneys. If these side effects occur in a patient, they will usually be detected through these tests before the patient even has any symptoms.”

Some drugs, says the doctor, have actually received FDA approval after studies of groups of as many as 5,000 patients. However, if the frequency of a side affect is one in 10,000, theoretically it may not be discovered until the drug is mass marketed and hundreds of thousands of patients are taking it.

“In situations like that, the FDA is blamed for not being more careful,” noted Dr. Krause, “but it would be cost prohibitive to run a study on such a large scale. If a patient takes and new drug outside a study and is developing liver failure, they may not know it, and they could even die. But, we monitor our patients much more carefully. I call them “guinea persons”, and I always tell them that if they do not get better on the medication we will take them off of it, usually after about a month, or sometimes even a couple of weeks.”

The direct benefits to the patient in include:

  • A chance to try a new medication if you are not responding to current treatment
  • Many studies include one year of medication at no cost
  • Compensation for time and travel
  • Aiding in the development of new treatment options

Our clinical trials are usually a win/win for everyone.

If interested, contact our office at (423) 698-4584, or visit our website www.clinsearch-us.com